Welcome to Novellus

A new American scratch kitchen restaurant in the heart of Main Street St Charles

Novellus is a new Main Street scratch kitchen and cocktails serving an twist on American and comfort food classics. Enjoy a delicious dinner in our dining room, brunch on our patio, or have a crafted cocktail or rare bourbon in our lounge.

Find Us

201 N Main St
St. Charles, MO 63301

Just enjoyed a delicious brunch at Novellus! Best Eggs Benedict and Biscuits and Gravy I’ve ever had, but the highlight of my experience was the Bloody Mary – outstanding! My compliments to their Chef and their Bartender.

Barb F

I wish I would have thought of taking pics of our meals before we dug in 🙁 Not only did they look amazing, but they tasted even better. The vibe here would be perfect for evening cocktails. Highly recommend.

James C

If you love crafted cocktails, amazing food, or need a new spot in St Charles for brunch, then Novellus is for you!

Jo O


201 N Main St
St. Charles, MO 63301

Our Hours

Mon-Fri 11am – 10pm
Sat 10am – 10pm
Sun Brunch 10am – 3pm